AstraZeneca's Tozorakimab meets primary endpoint in "pivotal" trial

(Alliance News) - AstraZeneca PLC on Monday reported positive phase three results for its ...

Alliance News 20 April, 2026 | 8:19AM
Email Form Facebook Twitter LinkedIn RSS

(Alliance News) - AstraZeneca PLC on Monday reported positive phase three results for its monoclonal antibody, Tozorakimab, meeting its primary endpoint in the Miranda trial in patients with chronic obstructive pulmonary disease.

The Cambridge, England-based pharmaceutical company said that in the "pivotal" trial, the monoclonal antibody demonstrated a statistically significant and meaningful reduction in the annualised rate of moderate-severe COPD exacerbations in the primary population of former smokers, along with the overall population.

AstraZeneca noted this included both former and current smokers, as well as patients across all blood eosinophil counts and all stages of lung function severity.

Almost 400 million people globally are diagnosed with COPD every year, said AstraZeneca, noting that it is the third leading cause of death globally.

AstraZeneca said the results follow on from the positive results from the phase three Oberon and Titania trials assessing Tozorakimab at a four-week dosing interval.

Shares in AstraZeneca fell 1.0% to 14,974.10 pence on Monday morning in London.

"These data further demonstrate tozorakimab's exciting potential as a first-in-class biologic with a truly differentiated mechanism of action that inhibits the signalling of the reduced and oxidised forms of IL-33 to address underlying drivers of COPD. We look forward to sharing the data with regulators and the scientific community as soon as possible," said Sharon Barr, executive vice president, BioPharmaceuticals R&D at AstraZeneca.

By Christopher Ward, Alliance News reporter

Comments and questions to newsroom@alliancenews.com

Copyright 2026 Alliance News Ltd. All Rights Reserved.

Email Form Facebook Twitter LinkedIn RSS

Securities Mentioned in Article

Security Name Price Change (%) Morningstar
Rating
AstraZeneca PLC 14,898.00 GBX -1.46

About Author

Alliance News

Alliance News provides Morningstar with continuously updating coverage of news affecting listed companies.

© Copyright 2025 Morningstar, Inc. All rights reserved.

Terms of Use        Privacy Policy        Modern Slavery Statement        Cookie Settings        Disclosures