AstraZeneca, Amgen Report Positive Tezepelumab Study Results

(Alliance News) - AstraZeneca PLC and Amgen Inc on Friday said positive full results from the ...

Alliance News 26 February, 2021 | 2:27PM
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(Alliance News) - AstraZeneca PLC and Amgen Inc on Friday said positive full results from the Navigator phase III trial of tezepelumab showed a reduction in the annualised asthma exacerbation rate in severe, uncontrolled asthma patients.

Tezepelumab blocks the action of thymic stromal lymphopoietin, an epithelial cytokine that plays a key role across the spectrum of asthma inflammation.

The Cambridge, England-based biopharmaceutical company also said tezepelumab demonstrated statistically significant improvements in every key secondary endpoint compared to placebo.

"These are ground-breaking results for the many patients with severe asthma who continue to face debilitating symptoms despite receiving standard of care inhaled medicines and currently approved biologics," said Andrew Menzies-Gow, director of the Lung Division, Royal Brompton Hospital, London, and principal investigator of the Navigator phase III trial.

"Tezepelumab has the potential to transform treatment for a broad population of patients with severe asthma regardless of their type of inflammation, including those with and without an eosinophilic phenotype," added Menzies-Gow.

Astra shares were trading 0.3% lower in London on Friday afternoon at 6,989.00 pence each. Amgen was up 0.6% to USD228.89 in the New York pre-market.

By Evelina Grecenko; evelinagrecenko@alliancenews.com

Copyright 2021 Alliance News Limited. All Rights Reserved.

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Securities Mentioned in Article

Security Name Price Change (%) Morningstar
Rating
AstraZeneca PLC 7,287.00 GBX 0.61
Amgen Inc 248.95 USD 0.84

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